The Pharmacological Management of Ketamine Use Disorder: A Systematic Review.
Journal of addiction medicine Emmert Roberts, Elizabeth Sanderson, Irene Guerrini 14 citations
A systematic review of pharmacological treatments for ketamine use disorder found only 12 studies (368 participants), including 1 controlled trial, 2 retrospective case series, and 9 case reports. All evidence was very low quality, with only descriptive outcomes reported. Benzodiazepine regimens and haloperidol showed potential utility for managing intoxication and withdrawal, while naltrexone, lamotrigine, and a combination of paliperidone palmitate and bupropion were reported as potentially useful for craving and relapse prevention. The review highlights a severe lack of rigorous research, with benzodiazepine regimens appearing most promising for future investigation in intoxication and withdrawal.