Effects of association between resveratrol and ketamine on behavioral and biochemical analysis in mice.
Journal of neural transmission (Vienna, Austria : 1996) August 1, 2024 Patrícia Zorzi Juliani, Talita Rodrigues, Getulio Nicola Bressan et al. 4 citations
Resveratrol, a phenol in grapes and wine, reduced locomotor and exploratory activity in mice, decreased exploration of new objects in a memory test, lowered MAO-A activity in the striatum, and increased IL-6 levels in the cortex. When combined with a low dose of ketamine (20 mg/kg), these effects were attenuated, and MAO-A activity also decreased in the cortex. No significant changes in oxidative stress markers were observed. Resveratrol alone did not appear to add to ketamine's effects on behavior, but its own effects on movement and exploration warrant further investigation.