Journal of neural transmission (Vienna, Austria : 1996)
January 1, 1996
M S Reid, K Hsu, K H Souza et al.
19 citations
In rats, ibogaine applied directly to the nucleus accumbens or striatum via microdialysis had a biphasic effect on extracellular dopamine: lower doses (10⁻⁶ M–10⁻⁴ M) decreased dopamine levels, while higher doses (5×10⁻⁴ M–10⁻³ M) increased them. The dopamine metabolite DOPAC was unaffected. Co-administration with naloxone or norbinaltorphimine blocked the dopamine decrease, suggesting involvement of kappa opioid receptors. The stimulatory effect at high doses was calcium-independent, not blocked by tetrodotoxin, but reduced by cocaine, reserpine, or alpha-methyl-para-tyrosine pretreatment. In striatal synaptosomes, ibogaine and harmaline inhibited dopamine uptake dose-dependently, indicating the stimulatory effect involves the dopamine transporter.
Journal of neural transmission (Vienna, Austria : 1996)
May 1, 2024
Fahd François Hilal, Jerome Jeanblanc, Chloé Deschamps et al.
8 citations
A review of preclinical studies in animal models examines two emerging approaches for alcohol use disorder: psychedelics and epigenetic drugs (epidrugs). Both treatments show potential benefits for reducing alcohol drinking, seeking, motivation, and relapse. Because psychedelics and epidrugs may share common and complementary mechanisms of action, there is an opportunity for exploring synergies between these approaches and their parallel effectiveness in treating AUD and associated psychiatric conditions.
Journal of neural transmission (Vienna, Austria : 1996)
August 1, 2024
Patrícia Zorzi Juliani, Talita Rodrigues, Getulio Nicola Bressan et al.
4 citations
Resveratrol, a phenol in grapes and wine, reduced locomotor and exploratory activity in mice, decreased exploration of new objects in a memory test, lowered MAO-A activity in the striatum, and increased IL-6 levels in the cortex. When combined with a low dose of ketamine (20 mg/kg), these effects were attenuated, and MAO-A activity also decreased in the cortex. No significant changes in oxidative stress markers were observed. Resveratrol alone did not appear to add to ketamine's effects on behavior, but its own effects on movement and exploration warrant further investigation.
Journal of neural transmission (Vienna, Austria : 1996)
July 1, 2003
H B Lebsanft, A Mayerhofer, K-A Kovar et al.
MDMA and three of its derivatives (MBDB, MDE, and MDA) all caused rats to turn in circles toward the side of a brain lesion that mimics Parkinson's disease. MDA produced the strongest effect. Blocking serotonin reuptake with citalopram reduced the turning caused by MDMA, but blocking serotonin synthesis with PCPA had only a small effect. This suggests that the rotational behavior induced by MDMA is not fully explained by serotonin release or by the drugs' direct dopamine-like activity.