Effects of ketamine on the severity of depression and anxiety following postoperative mechanical ventilation: a single-blind randomized clinical trial in Iran.
Acute and critical care May 1, 2024 Seyedbabak Mojaveraghili, Fatemeh Talebi, Sima Ghorbanoghli et al. 1 citation
In mechanically ventilated patients after craniotomy, ketamine reduced depression and anxiety more than a combination of midazolam and morphine. Fifty patients were randomly assigned to receive either ketamine or midazolam plus morphine during mechanical ventilation in the ICU. Depression scores were significantly lower in the ketamine group at 2 months and 6 months after discharge. Anxiety scores were significantly lower in the ketamine group at 2 weeks and 6 months after discharge. Ketamine appears effective for long-term prevention and treatment of anxiety and depression in this population, though larger studies are needed to confirm these findings.