Tieqiao Liu

From the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).

2 papers in the library · 7 citations · publishing 2021-2024

Papers

Widespread reductions in cortical thickness following ketamine abuse.

Journal of psychiatry & neuroscience : JPN January 1, 2024 Jinsong Tang, Qiuxia Wu, Chang Qi et al. 7 citations

Chronic, non-medical use of ketamine is associated with widespread thinning of the brain's outer layer, the cortex. Compared with healthy controls, 95 people with ketamine use disorder showed reduced cortical thickness in many regions, most extensively in the frontal and parietal lobes, including the dorsolateral prefrontal cortex and precuneus. No areas of increased thickness were observed. Greater estimated lifetime ketamine consumption correlated with thinner cortex in the right inferior parietal and right rostral middle frontal regions. These findings highlight potential long-term structural brain changes from non-medical ketamine use and serve as a reference for its antidepressant use.

DOI: 10.1503/jpn.230111 Full text Ketamine Neuroscience Drug-abuse Brain-structure +1

Widespread Cortical Thickness Reductions Following Non-medical Use of Ketamine: a Structural MRI Study of Individuals with Ketamine Dependence

medRxiv Preprint Server February 21, 2021 Jinsong Tang, Qiuxia Wu, Chang Qi et al. preprint

Long-term, non-medical use of ketamine is associated with reduced gray matter in the dorsal prefrontal cortex, and this study investigated whether similar cortical thinning occurs. Chronic ketamine users showed cortical thickness abnormalities compared to non-users, suggesting that recreational ketamine use may lead to structural brain changes beyond gray matter volume loss. The findings indicate potential neurotoxic effects of sustained illicit ketamine use on brain health, as observed through MRI scans.

DOI: 10.1101/2021.02.21.21252178 Full text Ketamine abuse Recreational ketamine use Illicit ketamine Ketamine dependence +11