Analysis of the mechanism by which ketamine affects astrocytes in Parkinsonian rats through the PI3K/AKT axis.
Cellular and molecular biology (Noisy-le-Grand, France) May 27, 2024 Yanhong Xiong, Jianwen Yuan, Luogeng Xu 1 citation
In a rat model of Parkinson's disease (PD), ketamine treatment alleviated behavioral deficits and brain pathology, reducing inflammation and oxidative stress. PD rats showed lower motor performance and ATPase activity, and higher α-synuclein levels. Ketamine improved these measures and suppressed the PI3K/AKT signaling pathway, promoting autophagy. Similar PI3K/AKT suppression was observed in a cell model using LPS-stimulated astrocytes. The findings suggest ketamine's potential therapeutic effects on PD are linked to inhibition of the PI3K/AKT axis.