Dynamic regulation of phosphorylation of NMDA receptor GluN2B subunit tyrosine residues mediates ketamine rapid antidepressant effects.
Pharmacological research July 1, 2024 Ke Wang, Xuan Tan, Kai-Mo Ding et al. 5 citations
Ketamine rapidly alleviates depression-like behaviors by restoring the balance of NR2B phosphorylation both inside and outside synapses in the medial prefrontal cortex. In mice subjected to chronic unpredictable stress, ketamine normalized abnormal levels of phosphorylated NR2B and the phosphatase STEP61 within one hour. The findings indicate that the rapid antidepressant effects of ketamine depend on dynamic regulation of NR2B phosphorylation, offering a new target for developing antidepressant treatments.