Pharmacotherapy for sleep disturbances in post-traumatic stress disorder (PTSD): A network meta-analysis.
Sleep medicine July 1, 2024 Andreas S Lappas, Eleni Glarou, Zoi A Polyzopoulou et al. 13 citations
A network meta-analysis of 99 randomized controlled trials with 10,481 participants examined the effects of various medications on sleep problems in people with post-traumatic stress disorder. Prazosin may be the most effective treatment for insomnia, nightmares, and poor sleep quality. Evidence indicates a lack of efficacy for SSRIs, Mirtazapine, z-drugs, and benzodiazepines, which are commonly prescribed. Risperidone and Quetiapine carry a high risk of causing somnolence without clear therapeutic benefit. Hydroxyzine, Trazodone, Nabilone, Paroxetine, and MDMA-assisted psychotherapy may be promising, but more research is needed. Underpowered comparisons and low confidence in estimates limit generalizability.