Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy.
Heliyon May 15, 2024 Yan-Jun Lin, Su-Li Chen, Xiang-Li Zheng et al. 7 citations
In female patients undergoing hysteroscopy, combining propofol with 0.2 mg/kg of esketamine required a median effective dose (ED50) of 1.95 mg/kg of propofol to prevent response to laryngeal mask airway insertion, while 0.3 mg/kg of esketamine lowered the ED50 to 1.60 mg/kg. The 95% effective doses were 2.22 mg/kg and 2.15 mg/kg, respectively. Although the higher esketamine dose reduced propofol needs, it led to significantly greater additional propofol doses and higher airway pressure. No serious adverse effects occurred. The authors recommend using 0.2 mg/kg esketamine with propofol for optimal conditions during LMA insertion in this population.