MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments.
Pharmacological reports : PR June 1, 2024 Katarzyna Kuczyńska, Katarzyna Bartkowska, Ruzanna Djavadian et al. 3 citations
Repeated exposure to the synthetic cathinone MDPV during infancy in mice impairs spatial working memory and object recognition memory in young adulthood, but does not affect hippocampus-dependent spatial learning and memory as measured by the Morris water maze. Hippocampal neurogenesis and synaptogenesis remain intact, and the memory deficits are not linked to disrupted hippocampal development. The effects are the same in both male and female mice.