Very Low-Dose Sublingual Ketamine for Borderline Personality Disorder and Treatment-Resistant Depression.
Cureus April 1, 2024 Mitchell Liester, Rachel Wilkenson, Barry Patterson et al. 3 citations
A woman with borderline personality disorder and treatment-resistant depression improved after taking very low doses of ketamine under the tongue. Ketamine, typically given intravenously, has shown rapid antidepressant effects and can also reduce borderline personality disorder symptoms when given repeatedly through a vein. A single previous case reported improvement with intranasal esketamine. This case suggests that very low-dose sublingual ketamine may be an effective treatment for psychiatric conditions like borderline personality disorder and co-occurring treatment-resistant depression.