A woman with borderline personality disorder and treatment-resistant depression improved after taking very low doses of ketamine under the tongue. Ketamine, typically given intravenously, has shown rapid antidepressant effects and can also reduce borderline personality disorder symptoms when given repeatedly through a vein. A single previous case reported improvement with intranasal esketamine. This case suggests that very low-dose sublingual ketamine may be an effective treatment for psychiatric conditions like borderline personality disorder and co-occurring treatment-resistant depression.
The article explores how the experience of time changes across different states of consciousness, such as near-death experiences and those induced by mystical practices or psychedelic medicines. It introduces new terms for additional dimensions of time-experience and reviews the potential benefits and methods for achieving higher states of consciousness.