Substance specific EEG patterns in mice undergoing slow anesthesia induction.
BMC anesthesiology May 3, 2024 David P Obert, David Killing, Tom Happe et al. 5 citations
Mice anesthetized with sevoflurane, propofol, ketamine, or dexmedetomidine show substance-specific changes in brain wave patterns recorded from electrodes on the cortex. Sevoflurane and propofol decreased theta/alpha band power and increased beta/gamma power around loss of righting reflex. Dexmedetomidine shifted activity toward lower frequencies, increasing delta waves. Ketamine produced stronger high-frequency activity. These patterns partly matched those seen in humans but differed notably in low frequencies. The findings highlight both the usefulness and limitations of mouse models for studying anesthesia-induced unconsciousness.