Ketamine-induced prevention of SD-associated late infarct progression in experimental ischemia.
Scientific reports May 3, 2024 A Zdunczyk, L Schumm, S O A Helgers et al. 5 citations
Spreading depolarizations (SDs) occur frequently in patients with malignant hemispheric stroke. In animal experiments, SDs cause secondary neuronal damage and infarct expansion during the initial period of infarct progression, but their influence during the delayed period is not well characterized. This study analyzed the impact of SDs in the delayed phase after cerebral ischemia and the potential protective effect of ketamine. Focal ischemia was induced in mice. 24 hours after occlusion, SDs were measured in three groups: control, SD induction with potassium chloride, and SD induction with potassium chloride plus ketamine. Spontaneous SDs occurred at 0.33 SDs/hour, increasing to 3.37 SDs/hour with potassium chloride.