Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023.
European archives of psychiatry and clinical neuroscience April 25, 2024 Li-Yuan Zhao, Guang-Fen Zhang, Xue-Jie Lou et al. 11 citations
Over the past two decades, research on the antidepressant effects of ketamine and its enantiomers has grown substantially, culminating in the approval of esketamine nasal spray for treatment-resistant depression. A bibliometric analysis of 4,274 publications from 2000 to 2023, using visualization tools, reveals two main research foci: the efficacy and safety of these compounds in treating depression, and the mechanisms underlying their rapid antidepressant effects. The rapid onset of ketamine's effects has spurred further investigation into its mechanisms and the search for new antidepressants with fewer side effects.