Differential effects of repeated fluoxetine and ketamine administration on behavioral and pharmacological stressor-induced depression of digging behavior in mice.
Experimental and clinical psychopharmacology October 1, 2024 Kaitlyn J Partridge, Todd M Hillhouse 1 citation
Digging behavior in mice is a stable and consistent compulsive-like behavior that can be reduced by both behavioral and pharmacological stressors, producing a depression-like state. A single swim stress significantly reduced digging for at least three days, with recovery by day seven. Repeated treatment with fluoxetine (10 mg/kg/day), but not ketamine, partially reversed swim stress-induced digging suppression on days three and seven. The pharmacological stressor yohimbine dose-dependently decreased digging, and repeated ketamine (10 mg/kg/day), but not fluoxetine, reversed yohimbine-induced digging suppression. These results indicate that stress-induced suppression of digging behavior is stimulus- and drug-dependent, requiring further investigation.