2-Fluorodeschloroketamine (2-FDCK), a new psychoactive substance similar to ketamine, was detected and quantified in three forensic cases: one of self-mutilation and two deaths. In peripheral blood, concentrations ranged from 457 to 5885 µg/L across the cases, and the main metabolites nor-2-FDCK, dihydro-nor-2-FDCK, and dihydro-2-FDCK were also found. Hair analysis in the two fatal cases showed 2-FDCK at approximately 4149 and 79824 pg/mg. Deschloroketamine (DCK) was present in all biological fluids and hair, but in one case it appeared to result from 2-FDCK metabolism rather than separate ingestion, suggesting the first report of DCK as a metabolite of 2-FDCK in both fluids and hair.
Ayahuasca, a psychedelic brew, shows promise in enhancing creativity and emotional well-being. In a study with 100 participants, 75% reported increased artistic inspiration after consumption, while 60% experienced improved mood and emotional clarity. The chemistry of ayahuasca involves harmaline, which may influence brain function. This highlights the intersection of psychedelics and the humanities, suggesting potential benefits for artists and creatives. Additionally, insights from cannabis and cannabinoid research can inform forensic toxicology and drug analysis in understanding these substances' effects on mental health.