Pretreatment Brain White Matter Integrity Associated With Neuropathic Pain Relief and Changes in Temporal Summation of Pain Following Ketamine.
The journal of pain September 1, 2024 Emily P Mills, Rachael L Bosma, Anton Rogachov et al. 5 citations
In people with neuropathic pain, white matter structure in the default mode network and a pathway connecting the medial prefrontal cortex to the periaqueductal gray is linked to how much ketamine reduces central sensitization, a key pain mechanism. Among 35 patients treated with ketamine, pretreatment fiber density in the anterior limb of the internal capsule correlated with pain relief (r = 0.48), and fiber density in the default mode network (r = 0.52) and the medial prefrontal cortex-periaqueductal gray pathway (r = 0.42) correlated with reduced temporal summation of pain, a marker of central sensitization. However, white matter structure did not distinguish responders from nonresponders.