Time-dependent antidepressant-like effects of reelin and ketamine in the repeated-corticosterone model of chronic stress.
Progress in neuro-psychopharmacology & biological psychiatry June 8, 2024 Kaylene K A Scheil, Carla L Sánchez-Lafuente, Brady S Reive et al. 5 citations
Chronic stress reduces reelin, a brain protein, in the hippocampus and causes depression-like behavior. A single dose of reelin or ketamine each reversed these behavioral and molecular effects within one hour, and the benefit lasted at least one week. When given together, reelin and ketamine showed additive effects after one week. The findings suggest that reelin-based treatments could become a new class of rapid-acting antidepressants.