The impact of ketamine on outcomes in critically ill patients: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials.
Acute and critical care February 1, 2024 Yerkin Abdildin, Karina Tapinova, Assel Nemerenova et al. 9 citations
A meta-analysis of 12 randomized controlled trials involving 805 intensive care unit patients found that ketamine was not superior to other agents for mortality, pain, opioid or midazolam consumption, or length of stay. The analysis favored ketamine for reducing delirium rates, but this finding was not robust in sequential analysis, indicating that more trials are needed.