Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial.
Anesthesia and analgesia October 1, 2024 Xinglong Xiong, Yi Shao, Dongxu Chen et al. 41 citations
A single intravenous dose of esketamine (0.25 mg/kg) given before anesthesia induction lowers the risk of postoperative delirium in adults undergoing on-pump cardiac valve surgery. In a randomized controlled trial of 112 patients (average age 52 years, 53.6% female), delirium occurred in 23.2% of those given esketamine versus 44.6% in the placebo group, a relative risk reduction of about half. Esketamine also reduced the number of patients with multiple delirium episodes and the hyperactive subtype. The results suggest esketamine is an effective preventive intervention for delirium in this surgical population.