Unique Effects of (R)-Ketamine Compared to (S)-Ketamine on EEG Theta Power in Rats.
Pharmaceuticals (Basel, Switzerland) February 1, 2024 Dóra Pothorszki, Szabolcs Koncz, Dóra Török et al. 7 citations
In rats, (R)-ketamine, but not (S)-ketamine, dose-dependently increases EEG theta power during wakefulness and REM sleep for 23 hours. Theta rhythm originates in the hippocampus and is linked to cognitive functions, attention, and decreased anxiety. This effect on a hippocampal function not affected by (S)-ketamine may relate to neural plasticity and memory encoding.