Correlation analysis between clinical effective emotional treatment and plasma N-methyl-D-aspartate receptor function-related indexes.
Frontiers in neuroscience January 1, 2025 Zuxing Feng, Yanli Li, Ying Cai et al. 2 citations
After effective antidepressant treatment in patients with acute major depressive disorder (MDD), plasma glutamate levels increased while levels of inflammatory cytokines (IL-17, IL-1β, IL-6, TNF-α, and IL-8) decreased. Greater improvement in cognitive impairment was associated with smaller changes in glycine. Improvements in depressive and anxiety symptoms, reductions in feelings of despair, and alleviation of somatic anxiety symptoms were linked to changes in inflammatory cytokines. These findings suggest that N-methyl-D-aspartate receptor (NMDAR)-related indicators and inflammatory markers change with effective treatment and may be associated with clinical outcomes.