Disrupted default mode network connectivity in migraine without aura
The Journal of Headache and Pain November 8, 2013 Alessandro Tessitore, Antonio Russo, Alfonso Giordano et al. 177 citations
In people with migraine without aura, the default mode network (DMN) shows reduced connectivity in prefrontal and temporal brain regions during resting-state functional MRI, compared to healthy controls. These functional differences were not linked to structural brain changes or to clinical and neuropsychological features of migraine. The findings suggest that DMN dysfunction may reflect a maladaptive response to stress, a behavioral pattern often seen in migraine patients.