Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis
medRxiv Preprint Server March 21, 2025 Leo R. Silberbauer, Benjamin Eggerstorfer, Paul Michenthaler et al. 1 citation preprint
Oral ketamine may offer a more accessible alternative to intravenous and intranasal routes for treating depression, as it is easier to administer and has established safety and efficacy for chronic pain patients at home. The text suggests that current delivery methods limit ketamine's availability to specialized centers, but oral administration could expand access to antidepressant therapy.