NOVEL MANAGEMENT OF DEPRESSION USING KETAMINE IN THE INTENSIVE CARE UNIT
medRxiv Preprint Server September 23, 2021 Nirmaljot Kaur, Siva Naga S. Yarrarapu, Abhishek R. Giri et al. preprint
Ketamine, a dissociative anesthetic that blocks glutaminergic NMDA receptors, can rapidly relieve depression. While previously used in outpatient settings for treatment-resistant depression, this work demonstrates its usefulness for managing depression in the intensive care unit (ICU), expanding the settings where this rapid antidepressant effect can be applied.