Effects of cannabis use on antidepressant treatment response to repetitive transcranial magnetic stimulation and ketamine
medRxiv Preprint Server June 28, 2023 Mohammad Ali Shenasa, Houtan Totonchi Afshar, Eric A. Miller et al. preprint
Cannabis use may weaken the antidepressant effects of ketamine and repetitive transcranial magnetic stimulation (rTMS). The antidepressant effects of these treatments rely on long-term potentiation and synaptic plasticity, but cannabis activates CB1 receptors, which can impair synaptic plasticity. This suggests that cannabis use might reduce the effectiveness of ketamine and rTMS for depression treatment.