Ketamine-Assisted Psychotherapy for Generalized Anxiety Disorder: A Comprehensive Case Report with Integrated Neurophysiological Imaging Using Magnetoencephalography
medRxiv Preprint Server February 25, 2025 J Cohen, AC Reichelt, R Zamyadi et al. 1 citation preprint
A male patient in his late 30s with generalized anxiety disorder and depressive symptoms received ketamine-assisted psychotherapy (KAP) and underwent magnetoencephalography (MEG) scans before and after four of six KAP sessions plus two integration sessions. Functional connectivity increased in four of five brain networks measured (default mode, attention, central executive, motor, and visual), alongside increased cortical beta activity, decreased theta oscillations, reduced scores on anxiety and depression scales, and improved attention. These results suggest that resting-state MEG can detect KAP-related brain network changes and may help monitor therapeutic outcomes.