Self-experience in MDMA assisted therapy of PTSD
medRxiv Preprint Server January 3, 2023 Bessel A. van der Kolk, Julie B. Wang, Rachel Yehuda et al. 2 citations preprint
A Phase 3 clinical trial tested MDMA-assisted therapy (MDMA-AT) against placebo with therapy for severe PTSD. 85% of participants reported early childhood trauma, linked to deficits in emotional coping. MDMA-AT significantly improved alexithymia, self-compassion, and altered self-capacities compared to therapy alone. These changes address transdiagnostic mental processes that often hinder treatment response.