Ketamine Produces a Long-Lasting Enhancement of CA1 Neuron Excitability
bioRxiv Preprint Server May 26, 2021 Grace N Jang, M Bruce MacIver 1 citation preprint
Ketamine, a fast-acting and long-lasting antidepressant, alters brain cell activity at the synaptic, neuronal, and circuit levels. Its antidepressant effects involve interactions with key brain receptors, specifically N-methyl-D-aspartate (NMDA) receptors, though the exact cellular mechanisms remain unclear. This study examined how ketamine changes the excitability of individual neurons and networks, and the duration of these effects, to better understand the therapeutic mechanism behind its rapid and lasting antidepressant benefits.