Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system
bioRxiv Preprint Server April 12, 2023 Malika S. Datta, Yannan Chen, Shradha Chauhan et al. 6 citations preprint
Repeated ketamine administration causes opposite effects on dopamine neurons in different brain regions: a decrease in midbrain areas linked to behavior states and an increase in the hypothalamus. It also alters nerve connections to the prefrontal cortex, striatum, and sensory areas. The findings suggest post-transcriptional regulation of structural plasticity. An unbiased whole-brain analysis reveals divergent brain-wide impacts of chronic ketamine on association and sensory pathways.