Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine
bioRxiv Preprint Server May 5, 2020 Alexander D Shaw, Suresh D Muthukumaraswamy, Neeraj Saxena et al. 2 citations preprint
Ketamine alters brain oscillations, increasing high-frequency gamma waves and reducing low-frequency alpha and theta waves. A thalamo-cortical model better explained these changes than a cortex-only model. The model showed that ketamine increases specific synaptic connections: from superficial pyramidal cells to inhibitory interneurons via AMPA and NMDA receptors, and within-layer-5 pyramidal cell gain control via GABA-A and NMDA receptors. Receptor time-constants remained unchanged. These findings support using generative models to understand oscillatory data and provide computational evidence that ketamine alters local neural coupling through multiple neurotransmitter systems.