Impaired glutamate reuptake induces synaptic mistuning in rat hippocampal slices, that can be counteracted by ketamine
bioRxiv Preprint Server January 25, 2022 Erika Vazquez Juarez, Ipsit Srivastava, Maria Lindskog 1 citation preprint
Mistuning of synaptic transmission may contribute to psychiatric disorders. Inhibiting glutamate transporters in hippocampal slices caused synaptic retuning, reducing synaptic strength and lowering the threshold for long-term potentiation (LTP). A rat model of depression with decreased glutamate transporters also showed a reduced LTP threshold. The antidepressant ketamine counteracted the effects of increased glutamate on synaptic retuning, suggesting its mechanism of action is restoring adequate synaptic tuning.