Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials
General Psychiatry June 18, 2020 Xiao-Mei Li, Zhan-Ming Shi, Hua Hu et al. 13 citations
A meta-analysis of four randomized controlled trials (239 participants) compared ketamine alone or ketamine plus propofol against propofol alone in patients with major depressive disorder receiving a single electroconvulsive therapy session. Ketamine alone and the combination showed greater improvement in depressive symptoms at days 1, 3, and 7 after treatment, and were associated with longer seizure duration and higher seizure energy index. Ketamine alone also increased eye-opening time. However, the overall quality of evidence was very low or low, indicating a need for higher-quality trials.