Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer's disease.
Alzheimer's research & therapy July 15, 2025 Briana K Chen, Holly C Hunsberger, Alicia Whye et al.
Combining the drugs (R,S)-ketamine and prucalopride improved memory retrieval in a mouse model of Alzheimer's disease, suggesting a new multimodal strategy for treating cognitive decline. The treatment was less effective in females than in males and its effects depended on the age of the mice. Chronic treatment also reduced a marker of neuroinflammation (GFAP) in the hippocampus of female mice.