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Alzheimer's research & therapy

ISSN 1758-9193

2 papers in the library · 41 citations · publishing 2024-2025

Papers

N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer's disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk.

Alzheimer's research & therapy May 1, 2024 Dan Cheng, Zhuo-Gui Lei, Kin Chu et al. 41 citations

Chronic treatment with the psychedelic N,N-dimethyltryptamine (DMT) alleviated cognitive impairment and reduced amyloid-beta accumulation in the hippocampus and prefrontal cortex of 3×TG-AD transgenic mice, a model of Alzheimer's disease. DMT restored decreased sigma-1 receptor levels, reinstated multiple mitochondria-associated membrane proteins, and prevented abnormal physical contact and calcium dynamics between the endoplasmic reticulum and mitochondria in both in vitro and in vivo pathological conditions. DMT also modulated oxidative phosphorylation and ATP synthase in an in vitro Alzheimer's model. The protective effects are linked to DMT's activation of the sigma-1 receptor and preservation of ER-mitochondria crosstalk, suggesting potential as a preventive and therapeutic agent against Alzheimer's disease.

DOI: 10.1186/s13195-024-01462-3 Full text Alzheimer’s disease Er-mitochondria crosstalk N,N-Dimethyltryptamine Cognitive impairment +5

Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer's disease.

Alzheimer's research & therapy July 15, 2025 Briana K Chen, Holly C Hunsberger, Alicia Whye et al.

Combining the drugs (R,S)-ketamine and prucalopride improved memory retrieval in a mouse model of Alzheimer's disease, suggesting a new multimodal strategy for treating cognitive decline. The treatment was less effective in females than in males and its effects depended on the age of the mice. Chronic treatment also reduced a marker of neuroinflammation (GFAP) in the hippocampus of female mice.

DOI: 10.1186/s13195-025-01804-9 Full text Ketamine Adjunctive treatment Neuroinflammation Prucalopride +9