Fatalities following DMT use: Two case reports and a review of the literature.
Journal of analytical toxicology July 9, 2025 Jade Pullen, Robert Moore, Rebecca Wood et al. 1 citation
Two deaths in the UK following DMT use occurred in the context of polydrug use, with both cases involving additional compounds that can increase serotonergic drive, potentially causing serotonin syndrome. DMT was detected in femoral blood at 0.23 mg/l and 0.24 mg/l. One case involved cocaine and amphetamine; the other involved venlafaxine and mirtazapine. A literature search found three previous fatalities after DMT use, all accidental, two during ayahuasca ceremonies. Polydrug use is increasingly common, and users of unregulated drugs should exercise caution when combining them with other unregulated drugs or prescribed medications.