The effects of dexmedetomidine and ketamine infusions on the inflammatory response in liver resection: A randomized double-blind placebo study.
Medicine July 4, 2025 İrem Ates, Esra Laloglu, Salih Kara et al. 2 citations
After liver resection surgery, infusions of either ketamine or dexmedetomidine reduced inflammation and pain compared to a control infusion. In the control group, inflammatory markers pentraxin 3, serum amyloid A, and hepcidin continued to rise 12 hours after surgery, whereas they began declining in both drug groups. Higher inflammation levels correlated with more severe pain. No difference in liver function was seen among the groups. The two drugs were similarly effective, with neither showing clear superiority.