Seizure control in glycine encephalopathy using the Ketamine-Dextromethorphan-Sodium benzoate triple therapy.
Epilepsy & behavior reports September 1, 2025 Laith Haddad, Samah Trad, Lama Charafeddine et al.
Neonatal glycine encephalopathy, a rare genetic disorder causing severe seizures, was successfully treated with a combination of intravenous ketamine, oral dextromethorphan, and sodium benzoate in a newborn. The patient's status epilepticus resolved, and developmental improvement was observed on follow-up. Intravenous ketamine use in neonates is rare, with only two prior cases reported. This is the first report of efficacy using this triple therapy, suggesting a potential intervention for managing intractable seizures in glycine encephalopathy.