Effects of Intranasal dexmedetomidine and esketamine for premedication on postoperative pain after tonsillectomy and adenoidectomy in children: a randomized clinical trial.
BMC anesthesiology July 1, 2025 Jun-Wei Qi, Chuang Li, Xin-Yuan Qiu et al. 2 citations
Preoperative use of a combination of intranasal dexmedetomidine and esketamine reduces postoperative pain in children undergoing tonsillectomy and adenoidectomy. Among 173 children, the combination group had a lower area under the curve for pain scores at rest within 24 hours (9.50) compared with dexmedetomidine alone (19.25) or saline (37.25). The combination also lowered the incidence of emergence delirium to 12.3% versus 44.8% in the control group. Heart rates were higher in the combination and control groups than in the dexmedetomidine-only group. No serious adverse events occurred.