Higher mindfulness is linked to fewer depressive symptoms in college students, partly because it reduces shyness and improves core self-evaluation. A chain mediation model using two samples (646 and 269 students) showed that mindfulness influences depression sequentially through shyness and then core self-evaluation. The findings suggest that mindfulness practices may help prevent or treat depressive symptoms, especially in shy students, by lowering shyness and boosting self-evaluation.
Preoperative use of a combination of intranasal dexmedetomidine and esketamine reduces postoperative pain in children undergoing tonsillectomy and adenoidectomy. Among 173 children, the combination group had a lower area under the curve for pain scores at rest within 24 hours (9.50) compared with dexmedetomidine alone (19.25) or saline (37.25). The combination also lowered the incidence of emergence delirium to 12.3% versus 44.8% in the control group. Heart rates were higher in the combination and control groups than in the dexmedetomidine-only group. No serious adverse events occurred.