Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Zhengyuan South Street, Jinfeng District, Yinchuan, Ningxia, 750000, People's Republic of China.
2 papers in the library · 89 citations · publishing 2018-2025
Mice exposed to chronic social defeat stress showed reduced spatial working memory and contextual fear memory, along with decreased levels of the NMDA receptor subunit NR2B, reduced long-term potentiation, and smaller NMDA receptor-mediated currents in the hippocampus. Ketamine treatment reversed these memory deficits and increased NR2B expression, LTP, and NMDA receptor-mediated currents. The findings suggest that depression-related memory dysfunction involves downregulation of hippocampal NR2B and synaptic plasticity, and that ketamine's antidepressant effects include restoring these measures.
Intraoperative infusion of low-dose esketamine (0.5 mg/kg/h) significantly reduced postoperative sleep disturbance (PSD) after laparoscopic cholecystectomy. In a randomized trial, PSD incidence was lower in the esketamine group than the placebo group on postoperative day 1 (58.1% vs. 81.4%), day 2 (11.6% vs. 44.2%), and day 3 (2.3% vs. 18.6%). The esketamine group also had lower postoperative pain scores and less intraoperative remifentanil use, with no difference in adverse reactions. Longer operation duration, higher ASA grade, and drain insertion were independent risk factors for PSD.