Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial.
BMC anesthesiology July 1, 2025 Yanan Wu, Yaning Yang, Xiaomei Wang et al. 9 citations
Intraoperative infusion of low-dose esketamine (0.5 mg/kg/h) significantly reduced postoperative sleep disturbance (PSD) after laparoscopic cholecystectomy. In a randomized trial, PSD incidence was lower in the esketamine group than the placebo group on postoperative day 1 (58.1% vs. 81.4%), day 2 (11.6% vs. 44.2%), and day 3 (2.3% vs. 18.6%). The esketamine group also had lower postoperative pain scores and less intraoperative remifentanil use, with no difference in adverse reactions. Longer operation duration, higher ASA grade, and drain insertion were independent risk factors for PSD.