Candidate Targets for Resilience Training to Reduce Transdiagnostic Risk for Mental Illness.
Schizophrenia bulletin June 17, 2025 Daphne J Holt, Rachel Sussman, Daniel Johnson et al. 1 citation
A four-session group-based Resilience Training (RT) program focusing on mindfulness skills reduced symptoms of psychosis and depression in 103 young adults with mild-to-moderate psychotic experiences or depressive symptoms. Participants showed increased mindfulness skills, decreased emotion reactivity, and reduced transdiagnostic symptoms after training. In a subset of 41 participants who underwent fMRI, training was associated with increased functional connectivity between the hippocampus and dorsolateral prefrontal cortex. The decrease in emotion reactivity fully mediated the link between skill acquisition and symptom reduction, suggesting that RT improves mental health by enhancing stress management. The findings support emotion reactivity as a target for preventive interventions.