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Tom Hsiang

School of Environmental Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

2 papers in the library · 35 citations · publishing 2023-2025

Papers

A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond

Biotechnology Advances August 31, 2023 Marco Pepe, Mohsen Hesami, Karla A. de la Cerda et al. 35 citations

Psychedelic mushrooms that contain psilocybin and related tryptamines have a long history of traditional use, and recent evidence suggests they may have therapeutic value for neurological and psychiatric disorders. This review covers the diversity and distribution of these mushrooms, methods for quantifying tryptamines and related metabolites, and the biosynthetic pathways that produce them. It also describes how psilocybin and related tryptamines are metabolized in humans and their pharmacological effects, including both beneficial and hazardous health implications. The authors discuss opportunities for using biotechnology and machine learning to engineer mushroom secondary metabolite profiles and outline a roadmap for future research.

DOI: 10.1016/j.biotechadv.2023.108247 Psilocybin Tryptamines Biotechnology Biology +2

Mycelium Growth and Development of Psilocybe spp. Mother Cultures on Agar-Based Media.

Journal of fungi (Basel, Switzerland) June 13, 2025 Marco Pepe, Mohsen Hesami, Livia Fleishmann et al.

Different genotypes of Psilocybe mushrooms grow differently on various agar-based media, and this is the first investigation to document those differences for four genotypes. The findings provide a foundation for developing genotype-specific cultivation protocols, which will help standardize and optimize mycelium growth and preservation for future clinical and industrial production of psilocybin.

DOI: 10.3390/jof11060450 Full text Psilocybe Mushroom production Mycology Explored +10