Investigating the Synergistic Neuroprotective Effects of Plant-Derived Antioxidants and the Psychedelic N,N-Dimethyltryptamine in Alzheimer's Disease Therapy.
Cells June 19, 2025 Júlia Jarne-Ferrer, Mercè Pallàs, Christian Griñán-Ferré et al. 2 citations
Combining the psychedelic molecule N,N-Dimethyltryptamine (NN-DMT) with five plant-derived bioactive compounds—Withanone, Apigenin, Bacoside A, Baicalin, and Thymoquinone—reduces age-related mobility problems, decreases amyloid-β plaque buildup, and improves survival under oxidative stress more effectively than any single compound alone. This synergistic effect was observed in a transgenic Caenorhabditis elegans model of Alzheimer's disease. The findings suggest that multi-target therapies addressing both protein aggregation and oxidative damage may offer a more promising direction for Alzheimer's treatment than single-drug approaches.