Exploring Microdosing Psychedelics as a Self-Managed Treatment for Premenstrual Dysphoric Disorder: A Qualitative Study
July 25, 2025 Rachael L. Sumner, Yuxin Ni, Suresh Muthukumaraswamy preprint
People with premenstrual dysphoric disorder (PMDD) microdose psilocybin to manage their symptoms, and all 14 interview participants reported benefit, though their regimens and treatment goals varied widely. PMDD is a severe mood disorder with limited treatment options. Participants described how PMDD harmed their quality of life and why they turned to microdosing. The findings suggest clinical trials into microdosing psychedelics for PMDD are warranted, as current information to support people engaging in this practice is lacking.