Psychedelic-Assisted Therapies for Psychosocial Symptoms in Cancer: A Systematic Review and Meta-Analysis
Current Oncology June 30, 2025 Haley D M Schuman, Chantal Savard, Raèf Mina et al. 9 citations
A systematic review and meta-analysis of 11 placebo-controlled randomized trials and 4 open-label studies found that psychedelic-assisted therapy with psilocybin or ketamine can reduce depression and anxiety in adults with cancer. Meta-analysis of four ketamine trials (354 participants) showed a large, rapid effect on depression and anxiety. Three psilocybin trials (101 participants) also showed a large effect on depression, though with wide variability. Non-randomized studies of MDMA and LSD suggested promise but were less rigorous. The authors conclude that psychedelic-assisted therapy may offer meaningful relief for cancer-related distress, but effects vary by therapeutic model and context, and more oncology-specific trials are needed.