Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials.
Pharmacy (Basel, Switzerland) July 21, 2025 Paula S C C Castro, Kae Leopoldo, Maria Olivia Pozzolo Pedro et al. 2 citations
Lysergic acid amide (LSA), consumed mainly from Convolvulaceae plant seeds, produces euphoria, hallucinations, nausea, and anxiety. Severe adverse outcomes include psychosis, hypertension, and hospitalization. Some evidence suggests potential therapeutic application for cluster headaches, but variability in dosing and online misinformation heighten risks. The systematic review of 17 human studies concludes that LSA poses significant health risks, exacerbated by a lack of scientific studies, and calls for further research to clarify its pharmacological profile and establish safety guidelines.