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Mcwelling Todman

Department of Psychology, The New School for Social Research, New York, NY 10011, USA.

3 papers in the library · 17 citations · publishing 2024-2025

Papers

The Effects of Psychotherapy on Single and Repeated Ketamine Infusion(s) Therapy for Treatment-Resistant Depression: The Convergence of Molecular and Psychological Treatment.

International journal of molecular sciences July 11, 2025 Sofia Sakopoulos, Mcwelling Todman 6 citations

Ketamine infusion therapy produces rapid antidepressant effects in people with treatment-resistant depression, and combining it with weekly psychotherapy yields the strongest symptom reduction. A retrospective chart review of patients receiving single or repeated ketamine infusions, with or without concurrent psychotherapy, measured depression severity using Beck Depression Inventory scores before treatment and 30 days after. All groups showed significant symptom improvement, but those who also attended weekly psychotherapy experienced the most pronounced effects. The number of infusions did not significantly change outcomes. The findings suggest that integrating psychotherapy with ketamine treatment enhances therapeutic response, possibly by taking advantage of ketamine-induced neural plasticity.

DOI: 10.3390/ijms26146673 Full text Ketamine infusion therapy Ketamine-assisted psychotherapy kap Rapid-acting antidepressant Treatment-resistant depression trd +2

Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories.

Progress in neuro-psychopharmacology & biological psychiatry April 2, 2025 C J Healy, Aaron Frazier, Stephen Kirsch et al. 6 citations

Adults with histories of childhood maltreatment who used psychedelic drugs with therapeutic intent at ceremonies or raves showed significant improvements in PTSD symptoms, complex PTSD symptoms, trait shame, social connectedness, and general connectedness from before the experience to two months afterward. The size of these improvements was large. Changes in these outcomes were linked to specific aspects of the acute psychedelic experience, such as subjective effects. The findings suggest that the social and psychological context of group psychedelic use may contribute to lasting mental health benefits for this population.

DOI: 10.1016/j.pnpbp.2025.111361 Full text PTSD Maltreatment Naturalistic Psychedelics +2

Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories

July 26, 2024 C. J. Healy, Aaron Frazier, Stephen Kirsch et al. 5 citations preprint

Adults with childhood maltreatment histories who used psychedelic drugs with therapeutic intent at ceremonies or raves showed significant improvements in PTSD symptoms, complex PTSD symptoms, trait shame, social connectedness, and general connectedness from before the experience to two months afterward, with effect sizes ranging from 0.73 to 1.12. The degree of improvement was linked to specific acute subjective effects of the psychedelic experience, suggesting that the psychosocial context of these group settings may contribute to therapeutic benefits.

DOI: 10.31234/osf.io/3rbxe Shame Longitudinal study Psychosocial Clinical psychology +8